We are looking for visionary investors, strategic partners, business alliance and concerned healthcare providers to advance our goals, to find and provide with possible cure for sleep apnea, and its related major fatal medical conditions.

We are in very early stage of clinical, research and business adventure in this one of the most explosive and largely untapped markets of the decade.

We would like to hear and see innovating ideas or proposals  from visionary investors and from business and financial partners or strategic alliances.

This web site is mainly for visionary investors, strategic business partners and concerned healthcare providers.

About Dr. Jin Zhou & SleepApneaUSA.net


Our Mission

SleepApneaUSA.net, founded by Dr. Jin Zhou, relied upon the latest research and clinically developed ZHT - Zhou's Hypoxicology Therapy to discover a possible cure for sleep apnea and provide an alternative care to those who can't tolerate CPAP,"sleeping mask".

Company Profile

SleepApneaUSA.net, founded by Dr. Jin Zhou, is a new business entity with clinically develop ZHT, and current offering teaching and clinical research on sleep apnea and sleep disordered breathing, chronic intermittent hypoxia related illness and diseases.

We have presently planned to explore further education of healthcare providers on sleep apnea, and our ZHT programs, and also the possiblities for ZHT to be integrading into current sleep care centers.

We also are planning to expand our ZHT clinical research, with other healthcare professionals participation, into many other major fatal medical conditions.

We are looking for visionary investors, strategic partners, business alliance and concerned healthcare providers to advance our goals, to find and provide with possible cure for sleep apnea, and its related major fatal medical conditions.

The Market — Sleep apnea, sleep-disordered breathing, and intermittent hypoxia have been identified and linked in latest research to almost all major fatal medical conditions, from heart attack, stroke, diabetes, COPD cancer, and major depressive disorders.

Sleep apnea is a serious, potentially life-threatening condition. It is a breathing disorder characterized by repeated collapse of the upper airway during sleep, with consequent cessation of breathing. Virtually all sleep apnea patients have a history of loud snoring. They may also unknowingly experience frequent arousals during the night, resulting in chronic daytime sleepiness or fatigue.

Sleep apnea appears to be as common as some better known diseases. It is estimated that 4 percent of middle-aged men and 2 percent of middle-aged women meet minimal criteria for sleep apnea syndrome.1 This compares to a 4.5 percent prevalence of asthma in middle-aged adults.2 Sleep apnea is more prevalent among the obese, in males, and in older individuals.3 There also seems to be a higher prevalence of sleep apnea in the hypertensive population.

As increasing in public awareness of sleep apnea and access and availability of sleep testing, the number of people suffering from sleep disordered breathing is growing faster than we can imagine, and it is estimated more than 50% of this population will fail in compliance of CPAP therapy or can't tolerate CPAP at all, thus the market and population for effective but alternative therapy is bigger than those under standard CPAP or surgical programs.

This market is one of the most explosive and largely untapped markets.
 

The Problem — Current main-stream treatment options are unsatisfactory, and the entire world is looking for a better or best solution.

Snoring Costs Over $88 Billion in Lost Productivity, Health Care Costs
Insurance Journal - June 8, 2006

"Patients who suffer from snoring and sleep apnea also may be suffering from depression and anxiety, and could have trouble concentrating at work, according to a new study. The result -- a cost to the U.S. economy of more than $88 billion in lost productivity and health care costs."

CPAP Merely Palliative in Obstructive Sleep Apnea Dec 2005 [Medscape (subscription)]

"NEW YORK (Reuters Health) Dec 21 - Treating obstructive sleep apnea (OSA) with nasal continuous positive airway pressure (CPAP) "is not a solution to the problem," researchers report in the December issue of the Annals of Neurology. The real problem is the underlying neurological lesions that cause disordered breathing and the solution, they say, is prevention of progression of OSA....

Summing up, he added that it is important to know the size and extent of the underlying neurological lesion before surgery. It is also "important to realize that nasal CPAP is not a complete solution and that non-compliance is a major problem... surgery may be a better solution."

Is obstructive sleep apnea syndrome a neurological disorder? A continuous positive airway pressure follow-up study.
Ann Neurol. 2005 Dec;58(6):880-7.
PMID: 16240364 [PubMed - in process]
Guilleminault C, Huang YS, Kirisoglu C, Chan A.

Obesity, High Blood Pressure Impacting Many U.S. Adults Ages 55-64 (Press Release- Dec 8, 2005) CDC Press

"Half of Americans aged 55-64 have high blood pressure – a major risk factor for heart disease and stroke – and two in five are obese, according to Health, United States, 2005, the government’s annual report to the President and Congress on the health of all Americans. The report was prepared by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics from data gathered by state and federal health agencies and through ongoing national surveys."

UAB Study Finds Link Between Sleep Apnea and High Blood Pressure (Press Releases from UAB) 11/16/2006

"Ubunama and colleagues with the UAB Hypertension Program found that the severity of sleep apnea is directly related to endothelial changes,......Sleep apnea is very under-diagnosed, according to Ubunama, particularly among patients with high blood pressure, and doctors rarely ask about their patients’ sleep habits. However, in UAB hypertension clinics, researchers have found the prevalence of sleep apnea in the population of resistant hypertension patients, specifically those who continue to experience uncontrolled high blood pressure on three or more medications, is approximately 85 percent."

More couples sleeping in double beds, survey says
AZ Central.com, AZ - Dec 21, 2005

"Thus the blooming of sleep-study clinics.

According to the American Academy of Sleep Medicine, there are now more than 800 accredited centers in the United States."

Waking up to sleep problems - NorthJersey.com, NJ

"The search for deep, uninterrupted, refreshing sleep has become a national obsession. It's driving everything from the development of new prescription sleeping pills to extensive bed makeovers in hotel chains."

Poway-based maker of sleep apnea pumps expects to continue growth trend (UNION-TRIBUNE, signonsandiego.com) December 30, 2005

"Twenty years later, sleep specialists estimate that 20 percent of adults have sleep apnea – and Farrell thinks it is closer to 30 percent. That means at least 18 million to 20 million people in the United States suffer from just that one sleep disorder. About 7 percent of those cases are moderate to severe. And only 4 million have been diagnosed, Farrell said. .........In fiscal 2005, which ended June 30, sales jumped 25 percent to $426 million, while net income grew 13 percent to $64.8 million, or $1.82 a share"

As stated above, due to poor compliance of CPAP programs, a huge population of people with even known diagnosis of obstructive sleep apnea (OSA) or central sleep apnea (CSA) is left with no choices but suffering hopelessly.

ZHT- Zhou's Hypoxicolgy Therapy: Maximally establishing or opening Upper Airway (Vocal Cord, Entire Trachea), maximizing respiration through maximizing, optimizing and rematch in respiratory ventilation and perfusion through body’s own physiological functions - upper airway defense reflexes, such as swallowing and cough augmentation.

ZHT is an non-surgical, non-pharmaceutical and manual therapy that can be used to benefit most clinical conditions.

Unlike other therapies currently used for sleep apnea, ZHT (Zhou's hypoxicology Therapy) identifies the root causes of sleep apnea, employs human natural power, human systemic defense reflexes, volitional resuscitations to eliminate and relieve not only sleep apnea but also many other intermittent hypoxia related health problems.

Based currently published research and ZHT clinical observations, ZHT may have potential to provide therapeutic values for diabetes, cancers, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS) and many more sleep disordered breathing (SDB) and chronic intermittent hypoxia related major illness and diseases.

SleepApneaUSA.net: ZHT for USA???

Sleep apnea, sleep-disordered breathing, and intermittent hypoxia have been identified and linked in latest research to almost all major fatal medical conditions, from heart attack, stroke, diabetes, COPD cancer, and major depressive disorders.

Sleep Apnea, Blood Pressure Linked (Newswise) Dec 11-2005

"Ubunama's suggestions are based on results of a study funded by the National Heart, Lung and Blood Institute and presented last month at the American Heart Association annual meeting. “We found a direct relationship between the severity of sleep apnea and cardiovascular changes associated with high blood pressure.”

Sleep disorders in systolic heart failure: A prospective study of 100 male patients. The final report.
Int J Cardiol. 2006 Jan 4;106(1):21-8.
PMID: 16321661 [PubMed - in process]

"CONCLUSIONS: 49% of male patients with systolic heart failure suffer from sleep apnea and 20% have PLMS. CSA occurs in about 37%, and OSA in 12% of patients. Habitual snoring and obesity are the hallmarks of OSA. In contrast, heart failure patients with CSA are commonly thin and mostly do not snore. Hallmarks of CSA are Class III New York Heart, artrial fibrillation, frequent nocturnal ventricular arrhythmias, low arterial PCO2 and LVEF <20%."

Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis.
JAMA. 2005 Dec 28;294(24):3124-30. Review.
PMID: 16380593 [PubMed - in process]

"CONCLUSIONS: Noninvasive ventilation reduces the need for intubation and mortality in patients with acute cardiogenic pulmonary edema. Although the level of evidence is higher for CPAP, there are no significant differences in clinical outcomes when comparing CPAP vs NIPSV."

Obstructive sleep apnoea-hypoapnoea syndrome reversibly depresses cardiac response to exercise.
Eur Heart J. 2006 Jan;27(2):207-15. Epub 2005 Nov 2.
PMID: 16267074 [PubMed - in process]

"CONCLUSION: OSAHS patients with normal resting left ventricular systolic function and no hypertension had a worse cardiac response to exercise than healthy subjects. In these patients, 3 months of CPAP improved both Qt and SV responses to exercise."

Current main-stream treatment options are unsatisfactory, and the entire world is looking for a better or best solution.

SleepApneaUSA.net, founded by Dr. Jin Zhou, relied upon the latest research and clinically developed ZHT - Zhou's Hypoxicology Therapy to discover a possible cure for sleep apnea and provide an alternative care to those who can't tolerate CPAP,"sleeping mask".

By now, if you are informed or aware of, from the latest scientific discovery on the association or relationship between sleep apnea, sleep disordered breathing and heart attack, hypertension, stroke, you may think or see how ZHT (Zhou's Hypoxicology Therapy) may have potential global values and impact on entire USA health and longevity.

How do we find out such potential values for ZHT?  [Items 1 - 20 of 101 from PubMed]

[Sleep apnea syndrome as a cause of secondary hypertension. A case report.]
Kardiol Pol. 2005 Nov;63(5):549-51. Polish.
PMID: 16362859 [PubMed - in process]

We invite you to review the Health, United States, 2005, the government’s annual report to the President and Congress on the health of all Americans. The report was prepared by the Centers for Disease Control and Prevention’s (CDC), you shall make your own determinations and conclusions.

	Obesity, High Blood Pressure Impacting Many U.S. Adults Ages 55-64 (Press Release- Dec 8, 2005) CDC Press "Half of Americans aged 55-64 have high blood pressure – a major risk factor for heart disease and stroke – and two in five are obese, according to Health, United States, 2005, the government’s annual report to the President and Congress on the health of all Americans. The report was prepared by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics from data gathered by state and federal health agencies and through ongoing national surveys..... Controlling high blood pressure and obesity is crucial for health, and particularly for baby boomers as they grow older," said HHS Secretary Mike Leavitt. "It's time to act against both conditions so more Americans can live longer, healthier lives."
Dec 8, 2005
	Health, United States, 2005 with Chartbook on Trends in the Health of Americans "Mortality Trends (page 18 of 25) Life expectancy and infant mortality rates are often used to gauge the overall health of a population. Life expectancy shows a long-term upward trend and infant mortality shows a long-term downward trend. In 2003 life expectancy at birth for the total population reached a record high of 77.6 years (preliminary data), up from 75.4 years in 1990 (table 27). In 2003 the preliminary infant mortality rate was 6.9 infant deaths per 1,000 live births, similar to the rate in 2002 (7.0 per 1,000). In 2002 the infant mortality rate increased for the first time in more than 40 years. The rise in infant mortality in 2002 was concentrated among neonatal deaths occurring in the first week of life, due largely to an increase in the number of infants born weighing less than 750 grams (1 pound 10 1/2 ounces) (figure 27 and table 22). Between 1950 and 2003 the age-adjusted death rate for the total population declined 43 percent to 831 deaths per 100,000 population (preliminary data). This reduction was driven largely by declines in mortality from heart disease, stroke, and unintentional injury (figure 29 and table 29). Mortality from heart disease, the leading cause of death, declined almost 4 percent in 2003 (preliminary data), continuing a long-term downward trend. The 2003 age-adjusted death rate for heart disease was 60 percent lower than the rate in 1950 (figure 29 and tables 29 and 31). Mortality from cancer, the second leading cause of death, decreased more than 2 percent in 2003 (preliminary data), continuing the decline that began in 1990. Overall cancer age-adjusted death rates rose from 1960 to 1990 and then reversed direction (figure 29 and tables 29 and 31). Mortality from stroke, the third leading cause of death, declined almost 5 percent in 2003 (preliminary data). Between 1950 and 2003, the age-adjusted death rate for stroke declined 70 percent (figure 29 and tables 29 and 31). In 2003 mortality from chronic lower respiratory diseases (CLRD), the fourth leading cause of death, decreased almost 5 percent from its peak in 1999 (preliminary data). Age-adjusted death rates for CLRD generally rose between 1980 and 1999, mainly as a result of steadily increasing death rates for females, most noticeably for females age 55 years and over (figure 29 and tables 29, 31, and 41). Mortality from unintentional injuries, the fifth leading cause of death, decreased more than 2 percent in 2003 (preliminary data). Age-adjusted death rates for unintentional injuries generally declined from 1950 until 1992 and then increased slightly (figure 29 and tables 29 and 31)."
	For Immediate Release: February 28, 2005 Contact: CDC National Center for Health Statistics Press Office, (301) 458-4800 E-mail: nchsquery@cdc.gov Deaths: Preliminary Data for 2003. NVSR Volume 53, Number 15. 48 pp. (PHS) 2004-1120 View/download PDF 1.3 MB [Page 3 of 48] "Causes of death The 15 leading causes(table B) remainedthe same for 2002 and 2003 except that Assault (homicide)dropped out of the 15 leading causes in 2003 and Parkinson’s disease entered the list as the 14th leading cause. The 15 leading causes of death in 2003 were as follows: 1) Diseases of heart; 2) Malignant neoplasms; 3) Cerebrovascular diseases; 4) Chronic lower respiratory diseases; 5) Accidents (unintentional injuries); 6) Diabetes mellitus; 7) Influenza and pneumonia; 8) Alzheimer’s disease; 9) Nephritis, nephrotic syndrome and nephrosis; 10) Septicemia; 11) Intentional self-harm (suicide); 12) Chronic liver disease and cirrhosis; 13) Essential (primary) hypertension and hypertensive renal disease; 14) Parkinson’s disease; 15) Pneumonitis due to solids and liquids."
Dec 8, 2005	Health, United States, 2005 with Chartbook on Trends in the Health of Americans Trend Tables The chartbook section is followed by 156 trend tables organized around four major subject areas: health status and determinants, health care utilization, health care resources, and health care expenditures. Overall He...
Dec 8, 2005	Health, United States, 2005 with Chartbook on Trends in the Health of Americans Trend Tables The chartbook section is followed by 156 trend tables organized around four major subject areas: health status and determinants, health care utilization, health care resources, and health care expenditures. Tables are...
Dec 23, 2005	Notice to Readers: Publication of Health, United States, 2005   Vol 54, No MM50;1288 CDC's National Center for Health Statistics has published Health, United States, 2005, the 29th edition of the annual report on the nation's health. The report includes 156 detailed trend tables organized around four broad subject... [PDF Version]
Dec 22, 2005	National Center for Health Statistics Health, United States, 2005 With Chartbook on Trends in the Health of Americans (12/2005) News Release Births, Marriages, Divorces, and Deaths: Provisional Data for May 2005 (12/2005) View/download PDF 211 KB Fertility, Family Pla...

SleepApneaUSA.net: ZHT for USA???

What Is Your Take?

CPAP Merely Palliative in Obstructive Sleep Apnea [(Reuters Health) Dec 21]